Holy Cross is a city located in Yukon-Koyukuk Census Area in the U.S state of Alaska. It nestled on the west bank of Ghost Creek Slough off the Yukon River. The total area of Holy Cross is 37.4 square miles at 62°11′53″N 159°46′24″W. It is elevated by 135 feet above sea level. It was incorporated on April 20, 1968. Holy Cross School in Grayling is operated by the Iditarod Area School District. In 2010, Holy Cross had a total population of 178. The population density was 4.64/sq mi. Recent job growth is negatively decreased by 4.24 percent. Holy Cross has Zip code 99602.