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O'Brien is an unincorporated village located in the U.S. state of Florida. It is within Suwannee County at the junction of County Road 349 in Branford to the north. It coordinates at 30°02′18″N 82°56′24″W. The elevation is 52 feet above sea level. As of the 2010 census data, it had a total population of 354. The population density was 1,714/sq mi. Recent job growth is positively increased by 0.41 percent. The average travel time is 19 minutes. It has Zip code 32071.
