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Keeseville is a hamlet located in Clinton and Essex counties, in New York, United States. The hamlet derived its name after the Keese family, early settlers from Vermont. Keeseville was formed along the Ausable River, which provided water power for mills and industrial development. It was originally called "Anderson Falls" by settlers from New England, who went into the area following the American Revolutionary War. Keeseville has zip codes 12911, 12924, and 12944.