The town of Mesilla is located in the county of Dona Ana. It covers a total area of 14.0 sq. km. The economy of the city revolves around industries involved in advertising, arts and crafts, construction, apparel, hotel, metal, education, liquor and beverages, enhancing the economy of the inhabitants of the city. Commercial spaces are utilized by arts and crafts shops, bed and breakfast accommodation inns, brew pubs, bridal shops, garden centers, health clubs, night clubs, restaurants and wineries, enhancing the economy of the city.